Tripartite motif containing 21 autoimmunity primes CD8 cell-mediated lung inflammation: an in vivo model of interstitial lung disease pathogenesis.
2026-06-26, Arthritis Research & Therapy (10.1186/s13075-026-03850-6) (online)Yulu Qiu, Qin Wu, Lu Liu, Wenjuan Zhao, Yue Wang, Fang Wang, and Wenfeng Tan (?)
Anti-Ro52 [Tripartite Motif Containing 21 (TRIM21)] antibodies are strongly associated with interstitial lung disease (ILD) in connective tissue diseases (CTDs), yet the underlying mechanisms remain elusive. This study aimed to elucidate the mechanisms by which TRIM21 autoimmunity drives ILD using an in vivo model.
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